| TITLE: | In vivo transfer of lipoprotein(a) into human atherosclerotic carotid arterial intima. | ||||||
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| AUTHOR: | Nielsen LB; Gronholdt ML; Schroeder TV; Stender S; Nordestgaard BG | ||||||
| AUTHOR AFFILIATION: | Department of Clinical Biochemistry, Rigshospitalet, Herlev, Denmark. | ||||||
| SOURCE: | Arterioscler Thromb Vasc Biol 1997 May;17(5):905-11 | ||||||
| NLM CIT. ID: | 97301553 | ||||||
| ABSTRACT: | The aim of this study was to compare the atherogenic potential of lipoprotein(a) [Lp(a)] and LDL by measuring the intimal clearance of these two plasma lipoproteins in the atherosclerotic intima of the human carotid artery in vivo. Autologous 131I-Lp(a) and 125I-LDL were mixed and reinjected intravenously 3 hours before elective surgical removal of the arterial intima in four patients. The intimal clearance of Lp(a) and LDL was 229+/-48 and 405+/-127 nL/cm2 per hour, respectively (paired t test; P=.12). The mass accumulation of Lp(a) (114+/-32 ng/cm2 per hour) was on average one 15th that of LDL (paired t test; P=.06), mainly reflecting a low plasma concentration of Lp(a) compared with LDL in the human subjects studied. In accordance with our previous observation in rabbits, there was a positive association between the intimal clearance of LDL and that of Lp(a) (r=.97, P=.03). Accordingly, high plasma levels of Lp(a) may share with LDL the potential for causing lipid accumulation in the arterial intima in humans. | ||||||
| MAIN MESH SUBJECTS: |
Atherosclerosis/*METABOLISM Carotid Arteries/*METABOLISM/PATHOLOGY Lipoprotein(a)/BLOOD/*METABOLISM | ||||||
| ADDITIONAL MESH SUBJECTS: |
Aged Centrifugation, Density Gradient Chromatography, Gel Electrophoresis, Agar Gel Female Human Iodine Radioisotopes Lipoproteins, LDL/BLOOD/METABOLISM Male Middle Age Support, Non-U.S. Gov't | ||||||
| PUBLICATION TYPES: | JOURNAL ARTICLE | ||||||
| LANGUAGE: | Eng | ||||||
| REGISTRY NUMBERS: |
0 (Iodine Radioisotopes) 0 (Lipoprotein(a)) 0 (Lipoproteins, LDL) | ||||||