Pauling recommended 6000 to 18000 mg ascorbic acid daily.Experience is that as much as 8000 mg may be required for six months to substantially lower total cholesterol.
Generally, the higher the dosage of vitamin C, the more rapid the response.
Bowel tolerance ( See [titrate] ) ranges from 4 to 20 g daily
Per Pauling's book HOW TO LIVE LONGER AND FEEL BETTER (1986), it is acceptable to add some backing soda to make swallowing easier.
On video Linus Pauling recommends supplement 5 g to 6 g (5000 to 6000 mg) lysine for advanced disease
We know of one 70-year old man whose 50% blockage was reversed on as little as 2500 mg of lysine daily for one month.
There is no reason to believe that there is additional heart benefit from supplementing more than 6000 mg daily, and 2000 to 3000 mg may work for many people
Many heart medications make patients worse. Specifically, the statin cholesterol lowering drugs (e.g. Lipitor ® and Zocor®) are known to block the synthesis of Coenzyme Q10 leading to muscle myopathy and heart failure.
Higher dosage of the statin cholesterol lowering drugs (80 mg) are increasing the cases of heart failure and cardiomyopathy. We believe that this causes resistant Angina pain - pain that is not eliminated by the Pauling vitamin C/lysine therapy. (See [statin side effects] for a detailed description of this issue.)
Common blood thinners block vitamin K causing rapid calcification of soft tissues. (See [211 medline citations] for a detailed description of this issue.)
There has been a change in the past year which may be due to the use of newer so-called "medical" stents which are coated with a chemotherapeutic agent that deadens or kills the inside of the artery. This approach, as well as stents with radiation pellets, eliminates any possibility that the Pauling therapy can work. The vitamin C/lysine therapy depends on the artery healing itself - properly. The new stents and procedures interfere with healing. (See [radiation alert] for a detailed description of this issue.)
Combining ideas from several different sources, including Dr. John Ely and Dr. Sherry Lewin, there is strong evidence that high blood sugar "crowds" out vitamin C from entering cells. This is called "Glucose-Ascorbate Antagonism (GAA)" and the basics are covered in this paper ( Reversing Diabetes Type II, Glucose-Ascorbate Antagonism, and their Impact on Reversing Heart Disease.
Vitamin C has an extremely short half-life, competes with glucose for Insulin-mediated transport into cells, and is broken down faster in the gut in the presence of carbohydrates. Additionally, if Thomas Smith is right, See: Our Deadly Diabetes Deception a membrane disturbance in diabetics would make it even more difficult for vitamin C to enter cells. The good news is that this cell membrane problem can be corrected by avoiding processed fats (trans fats and hydrogenated oils) and supplementing virgin Omega 3/6 oils. As blood sugar declines, more vitamin C becomes available to cells.
Keep blood sugar low and avoid carbohydrates for maximum effect of the Pauling therapy. R-Alpha Lipoic Acid (ALA) helps diabetics lower their blood sugar and ALA may be an important adjunct for people with both heart disease and Type 2 diabetes. More when we know more.
Owen Fonorow, Naturopath, Ph.D.
Sun Feb 26 11:17:31 CST 2006