Caveats

Why the Pauling Therapy may not work for you

Dosage
Blockages greater than 90%
Prescription Medications
Medical and Radiation Coated Stents
High Blood Sugar/Type II Diabetes

Daily Dosages

Dosages must be adequate and maintained for symptom relief. Ascorbic acid is the only form recommended. (For example, a calcium ascorbate form would provide too much calcium at these dosages. We have reports of failure using calcium ascorbate.)

Vitamin C (ascorbic acid) 6000 to 18000 mg daily
Pauling recommended 6000 to 18000 mg ascorbic acid daily.
Generally, the higher the dosage of vitamin C, the more rapid the response.
Bowel tolerance ( See [titrate] ) ranges from 4 to 20 g daily
Experience is that as much as 8000 mg may be required for six months to substantially lower total cholesterol.
Per Pauling's book HOW TO LIVE LONGER AND FEEL BETTER (1986), it is acceptable to add some backing soda to make swallowing easier.
Lysine 5000 mg daily
On video Linus Pauling recommends supplement 5 g to 6 g (5000 to 6000 mg) lysine for advanced disease
We know of one 70-year old man whose 50% blockage was reversed on as little as 2500 mg of lysine daily for one month.
There is no reason to believe that there is additional heart benefit from supplementing more than 6000 mg daily, and 2000 to 3000 mg may work for many people

Blockages greater than 90%

There must be blood flow. Great success reported when blood flow is 50% or more. Less success when blood flow is estimated at 10% of normal (90% blockage) and almost no success when the artery is 100% blocked.

Prescription Medications

Statins cause Cardiomyopathy
Many heart medications make patients worse. Specifically, the statin cholesterol lowering drugs (e.g. Lipitor ® and Zocor®) are known to block the synthesis of Coenzyme Q10 leading to muscle myopathy and heart failure.
Higher dosage of the statin cholesterol lowering drugs (80 mg) are increasing the cases of heart failure and cardiomyopathy. We believe that this causes resistant Angina pain - pain that is not eliminated by the Pauling vitamin C/lysine therapy. (See [statin side effects] for a detailed description of this issue.)
Blood Thinners (Coumadin/Warfarin/heparin)
Common blood thinners block vitamin K causing rapid calcification of soft tissues. (See [211 medline citations] for a detailed description of this issue.)

Medical and Radiation Coated Stents

Many patients on the Pauling therapy also had stents implanted before they began vitamin C and lysine, and for years there were no reported problems. In fact, almost every stent recepient reported "miraculous" results - until recently.

There has been a change in the past year which may be due to the use of newer so-called "medical" stents which are coated with a chemotherapeutic agent that deadens or kills the inside of the artery. This approach, as well as stents with radiation pellets, eliminates any possibility that the Pauling therapy can work. The vitamin C/lysine therapy depends on the artery healing itself - properly. The new stents and procedures interfere with healing. (See [radiation alert] for a detailed description of this issue.)

High Blood Sugar/Type II Diabetes

After more than a decade of great success with the Pauling therapy, we began getting reports of relapses in Type 2 diabetics. These individuals had great initial success, but required angioplasty/stent and or heart bypass after a considerable period of time. (In one case, I.V. Chelation therapy "worked wonders" for the individual who was again experiencing Angina.)

Combining ideas from several different sources, including Dr. John Ely and Dr. Sherry Lewin, there is strong evidence that high blood sugar "crowds" out vitamin C from entering cells. This is called "Glucose-Ascorbate Antagonism (GAA)" and the basics are covered in this paper ( Reversing Diabetes Type II, Glucose-Ascorbate Antagonism, and their Impact on Reversing Heart Disease.

Vitamin C has an extremely short half-life, competes with glucose for Insulin-mediated transport into cells, and is broken down faster in the gut in the presence of carbohydrates. Additionally, if Thomas Smith is right, See: Our Deadly Diabetes Deception a membrane disturbance in diabetics would make it even more difficult for vitamin C to enter cells. The good news is that this cell membrane problem can be corrected by avoiding processed fats (trans fats and hydrogenated oils) and supplementing virgin Omega 3/6 oils. As blood sugar declines, more vitamin C becomes available to cells.

Keep blood sugar low and avoid carbohydrates for maximum effect of the Pauling therapy. R-Alpha Lipoic Acid (ALA) helps diabetics lower their blood sugar and ALA may be an important adjunct for people with both heart disease and Type 2 diabetes. More when we know more.

Owen Fonorow, Naturopath, Ph.D.
Sun Feb 26 11:17:31 CST 2006

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